State-of-the-art review of goat TSE in the European Union, with special emphasis on PRNP genetics and epidemiology.
作者： Gabriele Vaccari , Cynthia H. Panagiotidis , Cristina Acin , Simone Peletto , Francis Barillet
关键词:
摘要: Scrapie is a fatal, neurodegenerative disease of sheep and goats. It also the earliest known member in family diseases classified as transmissible spongiform encephalopathies (TSE) or prion diseases, which includes Creutzfeldt-Jakob humans, bovine encephalopathy (BSE), chronic wasting cervids. The recent revelation naturally occurring BSE goat has brought issue TSE goats to attention public. In contrast scrapie, presents proven risk humans. BSE, however, difficult evaluate, our knowledge limited. Natural caprine scrapie been discovered throughout Europe, with reported cases generally being greatest countries highest populations. As susceptibility incubation period duration are most likely controlled by protein (PrP) gene (PRNP). Like PRNP sheep, shows significantly greater variability than that cattle
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