Genetic and Epigenetic Alterations in Urothelial Carcinoma
作者： Hikmat A. Al-Ahmadie , Gopa Iyer
DOI: 10.1007/978-1-4939-2044-0_20
关键词:
摘要: Many genetic aberrations in significant cancer-related genes and pathways have been described bladder cancer including recurrent somatic mutations copy number alterations, some of which may represent druggable targets. In addition, many involved epigenetic regulation are significantly mutated result inactivation these genes, indicating a functional significance potential role tumorigenesis cancer.
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Sabine Zöchbauer-Müller, Arthur Sagalowsky, John D. Minna, Bogdan Czerniak, Funda Vakar-Lopez, Adi F. Gazdar, Shinichi Toyooka, Arvind K. Virmani, Alfredo J. Farinas, Kiyomi O. Toyooka, Kenichi Harada, Riichiroh Maruyama, Aberrant Promoter Methylation Profile of Bladder Cancer and Its Relationship to Clinicopathological Features Cancer Research. ,vol. 61, pp. 8659- 8663 ,(2001)
Margaret A Knowles, Magali Williamson, None, Mutation of H-ras is infrequent in bladder cancer: confirmation by single-strand conformation polymorphism analysis, designed restriction fragment length polymorphisms, and direct sequencing. Cancer Research. ,vol. 53, pp. 133- 139 ,(1993)
David Cappellen, Catherine De Oliveira, David Ricol, Sixtina de Medina, Jérôme Bourdin, Xavier Sastre-Garau, Dominique Chopin, Jean Paul Thiery, François Radvanyi, Frequent activating mutations of FGFR3 in human bladder and cervix carcinomas. Nature Genetics. ,vol. 23, pp. 18- 20 ,(1999) , 10.1038/12615
Alan L. Hiti, Peter W. Nichols, Zippora Williams, Peter A. Jones, Yvonne C. Tsai, Donald G. Skinner, Allelic losses of chromosomes 9, 11, and 17 in human bladder cancer. Cancer Research. ,vol. 50, pp. 44- 47 ,(1990)
Raman P. Nagarajan, Shaun D. Fouse, Robert J. A. Bell, Joseph F. Costello, Methods for cancer epigenome analysis. Advances in Experimental Medicine and Biology. ,vol. 754, pp. 313- 338 ,(2013) , 10.1007/978-1-4419-9967-2_15
Tahar O Aboulkassim, Hélène LaRue, Patricia Lemieux, François Rousseau, Yves Fradet, Alteration of the PATCHED locus in superficial bladder cancer Oncogene. ,vol. 22, pp. 2967- 2971 ,(2003) , 10.1038/SJ.ONC.1206513
Joanna Phillips, DA Solomon, JS Kim, J Bondaruk, SF Shariat, ZF Wang, AG Elkahloun, T Ozawa, J Gerard, D Zhuang, S Zhang, Frequent truncating mutations of STAG2 in bladder cancer Nature Genetics. ,vol. 45, pp. 1428- 1430 ,(2013) , 10.1038/NG.2800
Isabelle Schwartz-Cornil, D Theodorescu, I Cornil, B Fernandez, R Kerbel, Overexpression of normal and mutated forms of HRAS induces orthotopic bladder invasion in a human transitional cell carcinoma. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 87, pp. 9047- 9051 ,(1990) , 10.1073/PNAS.87.22.9047
Xavier Langa, Elena López-Knowles, José A Lorente, Josep Lloreta, David G Pisano, Laia Richart, Daniel Rico, Rocío N Salgado, Adonina Tardón, Stephen Chanock, Simon Heath, Alfonso Valencia, Ana Losada, Ivo Gut, Núria Malats, Francisco X Real, Cristina Balbás-Martínez, Ana Sagrera, Enrique Carrillo-de-Santa-Pau, Julie Earl, Mirari Márquez, Miguel Vazquez, Eleonora Lapi, Francesc Castro-Giner, Sergi Beltran, Mònica Bayés, Alfredo Carrato, Juan C Cigudosa, Orlando Domínguez, Marta Gut, Jesús Herranz, Núria Juanpere, Manolis Kogevinas, Recurrent inactivation of STAG2 in bladder cancer is not associated with aneuploidy. Nature Genetics. ,vol. 45, pp. 1464- 1469 ,(2013) , 10.1038/NG.2799
Peter J Goebell, Margaret A Knowles, None, Bladder cancer or bladder cancers? Genetically distinct malignant conditions of the urothelium Urologic Oncology: Seminars and Original Investigations. ,vol. 28, pp. 409- 428 ,(2010) , 10.1016/J.UROLONC.2010.04.003