Allelic losses of chromosomes 9, 11, and 17 in human bladder cancer.

摘要: Abstract Twenty-five human bladder tumors were examined for loss of heterozygosity markers on chromosomes 6p, 9q, 11p, 14q, and 17p. These studies show that all the reduced to homozygosity in at least some tumors. They also confirmed earlier by Fearon et al. [Nature (Lond.), 318: 377–380, 1985] approximately 40% chromosome 11p. However, greatest frequency allelic was seen 9q (67% informative cases) 17p (63% with both being lost concordantly 10 out 20 Allelic has not been previously observed other cancers; however, deletions have reported breast, lung, colorectal carcinomas. The data raise interesting possibility losses specific might be a feature cancer particular differentiated cell type whereas harboring more generally acting tumor suppressor genes common cancers.