Modulation of murine self antigens by mycobacterial components.

摘要: Responses of γδ T cells to antigen are poorly understood. Murine double negative γ(+) generally increase in number late mixed lymphocyte reactions (Jones et al., 1988). In humans and mice, there instances allo-reactive directed at polymorphic products the major histocompatibility complex (MHC) (Bluestone 1988; Ciccone, 1989). addition, other recognise, or restricted by Class I-MHC-like molecules, TL, CD1, Qa (Bonneville 1989, Porcelli 1989; Vidovic al. These observations encourage hypothesis that recognise presenting molecules similar to, if not same as, those recognised αβ cells. However, it is unclear whether vivo, populations exploit high junctional diversity myriad peptides on such molecules. Alternatively, with cell receptors (TCRs) encoded Vγ Vδ genes may be selected primarily self (presenting) Such could induced stress, as transformation infection (Janeway al,