Recognition of a self major histocompatibility complex TL region product by gamma delta T-cell receptors.

摘要: Ligand specificity of a murine gammadelta T-cell receptor-expressing hybridoma (KN6) derived from adult thymocytes has been analyzed in detail. The molecule recognized by the KN6 receptor is expressed on syngeneic cells various sources (peritoneal macrophages, thymocytes, spleen cells, and Abelson leukemia virus-transformed cell lines) transformed arrested at an early stage development (e.g., PCC3 embryonal carcinoma cells). Linkage gene coding for ligand to major histocompatibility complex genes could be demonstrated testing reactivity congenic strains that differ only H-2. In addition, analysis recombinant indicates controlling located or distal TL region. Involvement this recognition process directly transferring after introduction productively rearranged gamma delta into alphabeta clone germ line transgenic mice. These observations raise possibility least some regulate hemopoietic maturation activation.