Peptide Synthesis: A Review of the Solid-Phase Method

摘要: Publisher Summary This chapter discusses the biological roles and chemical structures of an increasing number peptide protein hormones. The increased visibility peptides gives impetus to synthesis. Solid-phase synthesis offers many advantages over conventional solution because simplicity operation dramatic savings in time. method provides ideal means for has found numerous applications not only by chemists but also biochemists, biologists, pharmacologists, physiologists, endocrinologists, immunologists. There are four efficient methods bond formation which have a wide general application: azide method, mixed anhydride dicyclohexylcarbodiimide active ester method. two principal strategies assembling all amino acid residues into desired sequence: fragment condensation incremental chain elongation. Fragment allows greater flexibility choice protecting groups condensing is impeded danger racemization at carbon C-terminal carboxyl component.