Development and evaluation of vinpocetine inclusion complex for brain targeting
作者： Jiaojiao Ding , Jinfeng Li , Shirui Mao
DOI: 10.1016/J.AJPS.2014.08.008
关键词:
摘要: Abstract The objective of this paper is to prepare vinpocetine (VIN) inclusion complex and evaluate its brain targeting effect after intranasal administration. In the present study, VIN was prepared in order increase solubility. Stability constant (Kc) used for host selection. Factors influencing properties investigated. Formation identified by solubility study DSC analysis. administration studied rats. It demonstrated that mainly influenced cyclodextrin type, organic acids system pH host/guest molar ratio. Multiple component complexes can be formed addition citric acid, with improved more than 23 times. Furthermore, In vivo revealed administration, absolute bioavailability 88%. Compared intravenous injection, significant achieved delivery, index 1.67. conclusion, complex, a fast onset action good achieved. Intranasal route promising approach treatment CNS diseases.
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