Galactomannan and the Circulating Antigens of Aspergillus Fumigatus

摘要: Galactomannans (GM) are widely distributed polysaccharides amongst plant and microorganisms. In plants, mainly legumes, they reserve composed of linear β(1–4) mannopyranosyl residues with single stubs α galactopyranosyl groups joined by (1–6) linkages along the chain (Dey, 1978). contrast to GMs associated vertebrate mycopathogens known stimulate host defense reaction (Reiss, 1986). Their fundamental structure is different from GMs. fungi, most contain mannans a great variety side structures (Gander, 1974; Barreto-Bergter Gorin, 1983). Man substituted at C-2, Galp C-4 Galf C-5 non-reducing end units commonly found in chains fungi. Galactofuranosyl have been studied more thoroughly because presently considered be immunodominant fungi (Bennett et al., 1985; Notermans 1988). However, length, branching point phosphorylation galactose vary fungus (Barreto-Bergter For example, 8–10 per galactofuran Penicillium charlesii (Gander al.,1974) whereas only non reducing group galactofuranose (1–2) linkage mannan backbone detected Dermatophytes (Bishop 1965, 1966). The GM peptido-GM Cladosporium phosphorus Aspergillus not phosphorylated (Lloyd, 1970; Gander 1981).