Organic Dust Toxic Syndrome

摘要: Organic dust toxic syndrome (ODTS) and hypersensitivity pneumonitis (HP) are associated with inhalation of high concentrations organic materials, particularly agricultural materials such as from grain, hay, or silage contaminated microorganisms (Pratt May 1984; Lecours,et al. 1986; et Pratt 1990). Although initial work was farming, one should recognize that workers involved in wood processing, large-scale production animal feed, treatment disposal sewage garbage by composting, various bioindugtrial processes may be exposed to their products. HP, also known extrinsic allergic alveolitis, has been recognized for a very long time occurs variety occupational settings (Parker 1992). Farmer’s lung disease (FLD) is the most familiar form HP agriculture. The term “pulmonary mycotoxicosis” applied ODTS differentiate it FLD underscore apparent importance fungi and/or metabolic products (Emanuel 1975). Attempts implicate mycotoxins were limited, both number scope, failed reveal significant amounts those few which sought samples collected outbreaks (May 1986). New continue described fumonisins, example, now considered an especially important group because frequency occurrence severity toxicity, not until 1988. presence levels bacteria since found hallmark (Dutkiewicz 1989; Olenchock noninfectious flu-like illness, characterized fever, malaise, myalgia, neutrophilic inflammation lower respiratory tract (Lecours Parker Hypersensitivity many features common ODTS, including similar exposure clinical symptoms 1975; illnesses appear involve parenchyma, they mediated same mechanisms. Notably, lymphocytic infiltrate into airways, suggesting due cell-mediated reaction. Prevalence individuals chronically potential antigens ranges 0.03 0.42% farming populations much 15% office ventilation systems