Potential inhibition of the neuro-neoplastic interactions: the clue of a GPCR-targeted therapy.

摘要: Other sections of this monograph, dedicated to neuronal activities in tumor tissue, have highlight the chief influence neurotrophins, neurotransmitters, adhesion, guidance molecules and different nerve cell markers progression, but also for prognostic, therapy survey cancers. The G-protein-coupled receptors (GPCR) are among most successful promising target proteins drug discovery therapeutic research. GPCR frequently overexpressed cancer cells, an interesting property imaging or a targeted radiotherapy, using radiolabeled ligand derivatives. microenvironment contains number ligands (e.g., bioactive peptides, biogenic amines, purins, chemokines), known regulate proliferation, migration survival both tumoral neural cells that may be key actors neuro-neoplastic interactions. Here will reviewed potential utilization substances selected choice GPCR, especially neuropeptide receptors, novel concept therapy, concerning numerous types cancers where neurons infiltrate mass those malignant invade branches (perineural invasion). Some molecular mechanisms linked these (or linking other membrane co-receptors), involved processes, considered.