The impact of the Tumor Microenvironment on the Properties of Glioma Stem-Like Cells

摘要: Glioblastoma (GBM) is the most common and highly malignant primary brain tumor patients affected with this disease exhibit a uniformly dismal prognosis. Glioma stem-like cells (GSCs) are subset of within bulk that possess self-renewal multi-lineage differentiation properties similar to somatic stem cells. These also at apex cellular hierarchy cause initiation expansion after chemo-radiation. traits make them an attractive target for therapeutic development. Because GSCs dependent on microenvironment their growth, because non-tumorigenic cell types in microenviroment can influence GSC phenotypes treatment response, better understanding these needed. In review we provide focused overview contributions from homing, maintenance, phenotypic plasticity, initiation. The interaction vascular compartment, mesenchymal cells, immune system normal discussed. Studies mechanistic insight into each GSC-microenvironment interactions warranted future.