Efficacy and safety of cisplatin versus miriplatin in transcatheter arterial chemoembolization and transarterial infusion chemotherapy for hepatocellular carcinoma: A randomized controlled trial
作者： Kentarou Otsuji , Koji Takai , Yoichi Nishigaki , Shougo Shimizu , Hideki Hayashi
DOI: 10.1111/HEPR.12376
关键词:
摘要: AIM Transcatheter arterial chemoembolization (TACE) and transarterial infusion chemotherapy (TAI) are the main therapeutic strategies for treatment of advanced hepatocellular carcinoma (HCC). We conducted a randomized controlled trial to compare efficacy safety cisplatin miriplatin in TACE TAI. METHODS Patients with HCC indication or TAI were randomly assigned receive either (49 patients per group) between April 2010 May 2013. The primary end-point was effect (TE) 3 months after initial treatment, secondary overall survival. RESULTS TE could be evaluated 26 group 20 group. In group, 11 (42.3%) 15 (57.7%) classified as showing TE3 + 4 TE1 + 2, respectively, while each number nine (45.0%) (55.0%) (P = 0.8551). Furthermore, no significant difference survival found two groups all (P = 0.905) those treated only (10 eight group; P = 0.695). showed better than TE1 + 2 (P = 0.0263). Grade 4 higher adverse event did not occur Creatinine levels rose 3 days (P = 0.0397). CONCLUSION Cisplatin had equal TAI, but should avoided renal dysfunction inadequate hydration. Good improved
sci-hub.se 参考文章(27)
Iwao Ikai, Toru Shimno, Shigeki Arii, Kenichiro Enooku, Hiroshi Igaki, Kenichi Takayasu, Masao Omata, Tadatoshi Takayama, Shinichi Kora, Hidemasa Takao, Yasuhiko Sugawara, Yutaka Matsuyama, Kayo Nojiri, Masatoshi Okazaki, Ryosuke Tateishi, Kenji Ino, Norihiro Kokudo, Shigeru Kiryu, Eriko Goto, Tatsuya Yamashita, Shuichi Kaneko, Seiji Kawasaki, Hisashi Nakayama, Kiyoshi Hasegawa, Sumihito Tamura, Hiroshi Imamura, Kuni Ohtomo, Takahisa Sato, Masatoshi Kudo, Hiroyuki Sugo, Masaaki Akahane, Masatoshi Makuuchi, Kuniaki Arai, Yasushi Uchino, Shinji Tanaka, The committee for revision of the Clinical Practice Guidelines for Hepatocellular Carcinoma Hepatology Research. ,vol. 40, pp. 2- 144 ,(2010)
Mitsuaki Maeda, Takuma Sasaki, Noriko A. Uchida, Liposoluble platinum(II) complexes with antitumor activity. Japanese Journal of Cancer Research. ,vol. 77, pp. 523- 525 ,(1986) , 10.20772/CANCERSCI1985.77.6_523
Kazutoshi Okabe, Toru Beppu, Katsuki Haraoka, Yoshihiro Oh-Uchida, Sadahiro Yamamura, Shinjiro Tomiyasu, Tsuyoshi Yamanaka, Osamu Sano, Toshiro Masuda, Akira Chikamoto, Shigetoshi Fujiyama, Hideo Baba, None, Safety and short-term therapeutic effects of miriplatin-lipiodol suspension in transarterial chemoembolization (TACE) for hepatocellular carcinoma Anticancer Research. ,vol. 31, pp. 2983- 2988 ,(2011)
Tatsuo Ueda, Satoru Murata, Daisuke Yasui, Takahiko Mine, Shinichiro Kumita, Comparison of the antitumor efficacy of transcatheter arterial chemoembolization with a miriplatin‐iodized oil suspension and a cisplatin‐iodized oil suspension for hepatocellular carcinoma Hepatology Research. ,vol. 43, pp. 1071- 1077 ,(2013) , 10.1111/HEPR.12212
Shiro Miyayama, Masashi Yamashiro, Yoshihiro Shibata, Masahiro Hashimoto, Miki Yoshida, Kazunobu Tsuji, Fumihito Toshima, Osamu Matsui, Comparison of local control effects of superselective transcatheter arterial chemoembolization using epirubicin plus mitomycin C and miriplatin for hepatocellular carcinoma Japanese Journal of Radiology. ,vol. 30, pp. 263- 270 ,(2012) , 10.1007/S11604-011-0043-6
Josep M Llovet, Sergio Ricci, Vincenzo Mazzaferro, Philip Hilgard, Edward Gane, Jean-Frédéric Blanc, Andre Cosme De Oliveira, Armando Santoro, Jean-Luc Raoul, Alejandro Forner, Myron Schwartz, Camillo Porta, Stefan Zeuzem, Luigi Bolondi, Tim F Greten, Peter R Galle, Jean-François Seitz, Ivan Borbath, Dieter Häussinger, Tom Giannaris, Minghua Shan, Marius Moscovici, Dimitris Voliotis, Jordi Bruix, None, Sorafenib in Advanced Hepatocellular Carcinoma The New England Journal of Medicine. ,vol. 359, pp. 378- 390 ,(2008) , 10.1056/NEJMOA0708857
Josep M Llovet, Jordi Bruix, Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival Hepatology. ,vol. 37, pp. 429- 442 ,(2003) , 10.1053/JHEP.2003.50047
Yo Sasaki, Shingi Imaoka, Hiroshi Kasugai, Makoto Fujita, Seiichi Kawamoto, Shingo Ishiguro, Junnosuke Kojima, Osamu Ishikawa, Hiroaki Ohigashi, Hiroshi Furukawa, Hiroki Koyama, Takeshi Iwanaga, A new approach to chemoembolization therapy for hepatoma using ethiodized oil, cisplatin, and gelatin sponge Cancer. ,vol. 60, pp. 1194- 1203 ,(1987) , 10.1002/1097-0142(19870915)60:6<1194::AID-CNCR2820600607>3.0.CO;2-T
Geoffrey Falkson, Louise M. Ryan, Lewis A. Johnson, Ian W. Simson, Barend J. Coetzer, Paul P. Carbone, Richard H. Creech, Allan J. Schutt, A random phase II study of mitoxantrone and cisplatin in patients with hepatocellular carcinoma: An ECOG study Cancer. ,vol. 60, pp. 2141- 2145 ,(1987) , 10.1002/1097-0142(19871101)60:9<2141::AID-CNCR2820600903>3.0.CO;2-4
Masafumi Ikeda, Seishi Maeda, Junji Shibata, Ryushi Muta, Hiroshi Ashihara, Motohiko Tanaka, Shigetoshi Fujiyama, Kimio Tomita, Transcatheter arterial chemotherapy with and without embolization in patients with hepatocellular carcinoma. Oncology. ,vol. 66, pp. 24- 31 ,(2004) , 10.1159/000076331