Transcatheter arterial chemotherapy with and without embolization in patients with hepatocellular carcinoma.
作者： Masafumi Ikeda , Seishi Maeda , Junji Shibata , Ryushi Muta , Hiroshi Ashihara
DOI: 10.1159/000076331
关键词:
摘要: Objective: This study compared the antitumor effect, adverse effects and survival between transcatheter arterial embolization (TAE) infusion chemotherapy (TAI) in patients with hepatocellular carcinoma (HCC). Methods: The population consisted of 168 consecutive advanced HCC treated treatments using cisplatin suspended lipiodol. Among these, 74 were TAE, remaining 94 TAI. Results: There no significant differences any baseline characteristics except hemoglobin, platelets, albumin, glutamic pyruvic transaminase. Complete or partial tumor response was achieved 54 (73%) TAE group 48 (51%) TAI (p < 0.01). two treatment-related deaths caused by acute hepatic failure renal group. Nausea deterioration serum transaminase after significantly more severe than Median time rates at 5 years 3.1 25% group, 2.5 18% = 0.37). Conclusion: has a higher effect TAI, but does not improve HCC.
sci-hub.se 参考文章(29)
David R. Cox, Regression Models and Life-Tables Springer Series in Statistics. ,vol. 34, pp. 527- 541 ,(1992) , 10.1007/978-1-4612-4380-9_37
Kenichiro Nakakuma, Seiki Tashiro, Takehisa Hiraoka, Kuninori Uemura, Toshimitsu Konno, Yoshimasa Miyauchi, Ikuzo Yokoyama, Studies on anticancer treatment with an oily anticancer drug injected into the ligated feeding hepatic artery for liver cancer Cancer. ,vol. 52, pp. 2193- 2200 ,(1983) , 10.1002/1097-0142(19831215)52:12<2193::AID-CNCR2820521203>3.0.CO;2-R
E. L. Kaplan, Paul Meier, Nonparametric Estimation from Incomplete Observations Springer Series in Statistics. ,vol. 53, pp. 319- 337 ,(1992) , 10.1007/978-1-4612-4380-9_25
Shuichi Okada, Transcatheter arterial embolization for advanced hepatocellular carcinoma: The controversy continues Hepatology. ,vol. 27, pp. 1743- 1744 ,(1998) , 10.1002/HEP.510270639
K Takayasu, Y Shima, Y Muramatsu, N Moriyama, T Yamada, M Makuuchi, H Hasegawa, S Hirohashi, Hepatocellular carcinoma: treatment with intraarterial iodized oil with and without chemotherapeutic agents. Radiology. ,vol. 163, pp. 345- 351 ,(1987) , 10.1148/RADIOLOGY.163.2.3031724
R Yamada, M Sato, M Kawabata, H Nakatsuka, K Nakamura, S Takashima, Hepatic artery embolization in 120 patients with unresectable hepatoma. Radiology. ,vol. 148, pp. 397- 401 ,(1983) , 10.1148/RADIOLOGY.148.2.6306721
Gordon J‐H Park, Betty Pc Lin, Meng C Ngu, D Brian Jones, Peter H Katelaris, Aspartate aminotransferase: alanine aminotransferase ratio in chronic hepatitis C infection: is it a useful predictor of cirrhosis? Journal of Gastroenterology and Hepatology. ,vol. 15, pp. 386- 390 ,(2000) , 10.1046/J.1440-1746.2000.02172.X
R Peto, M C Pike, P Armitage, N E Breslow, D R Cox, S V Howard, N Mantel, K McPherson, J Peto, P G Smith, Design and analysis of randomized clinical trials requiring prolonged observation of each patient. I. Introduction and design. British Journal of Cancer. ,vol. 34, pp. 585- 612 ,(1976) , 10.1038/BJC.1976.220
S Maeda, Survival and local recurrence rates of hepatocellular carcinoma patients treated by transarterial chemolipiodolization with and without embolization Hepatology Research. ,vol. 23, pp. 202- 210 ,(2002) , 10.1016/S1386-6346(01)00174-7
Junji Shibata, Shigetoshi Fujiyama, Tatsuo Sato, Shuichi Kishimoto, Shoji Fukushima, Masahiro Nakano, Hepatic arterial injection chemotherapy with cisplatin suspended in an oily lymphographic agent for hepatocellular carcinoma Cancer. ,vol. 64, pp. 1586- 1594 ,(1989) , 10.1002/1097-0142(19891015)64:8<1586::AID-CNCR2820640805>3.0.CO;2-E