25-Hydroxyvitamin D Assays and Their Clinical Utility

摘要: The vitamin D status of an individual is best assessed by measurement circulating 25-hydroxyvitamin [25(OH)D]. Challenges to this analyte include the hydrophobic nature and presence two forms D, ergocalciferol cholecalciferol (vitamin D2 D3, respectively). absence standard calibrators contributes between-laboratory bias in 25(OH)D measurement. current state reviewed; modest differences between methodologies persist. Until there assay standardization, subsequent evidence-based consensus, it premature recommend screening Targeted those at increased risk for deficiency, most likely have a prompt positive response supplementation, seems appropriate.