Nonfasting cholesterol and triglycerides and association with risk of myocardial infarction and total mortality: the Copenhagen City Heart Study with 31 years of follow‐up

摘要: .  Langsted A, Freiberg JJ, Tybjaerg-Hansen Schnohr P, Jensen GB, Nordestgaard BG (Herlev Hospital, Herlev; University of Copenhagen; Bispebjerg Hospital; and Rigshospitalet, Copenhagen O, Denmark). Nonfasting cholesterol triglycerides association with risk myocardial infarction total mortality: the City Heart Study 31 years follow-up. J Intern Med 2011; 270: 65–75. Objectives.  We compared ability very high levels nonfasting to predict mortality. Design.  Prospective study from 1976 1978 until 2007. Setting.  Danish general population. Participants.  Randomly selected population 7581 women 6391 men, whom 768 1151 developed 4398 4416 died, respectively. Participation rate was 72%, follow-up 100% complete. Less than 2% participants were taking lipid-lowering therapy. Results.  Compared <5 mmol L−1, multivariate-adjusted hazard ratios for ranged 1.3 [95% confidence interval (CI): 0.9–1.8] a level 5.0–5.99 mmol L−1 2.5 (95%CI: 1.6–4.0) ≥9 mmol L−1 (trend: P < 0.0001). <1 mmol L−1, 1.5 1.2–1.8) 1.0–1.99 mmol L−1 4.2 2.5–7.2) ≥5 mmol L−1 (p<0.0001). In corresponding 1.2 1.0–1.5) 5.3 3.6–8.0) (P < 0.0001) 1.0–1.6) 2.1 1.5–2.8) (P < 0.0001). Increasing not consistently associated mortality in P = 0.39) or men (P = 0.02). By contrast, <1 mmol L−1, 1.1 1.0–1.2) 2.0 1.5–2.9) P 0.0001); 1.2–1.7) < 0.0001). Conclusions.  Stepwise increasing similarly stepwise infarction, being best predictor men. Even more surprisingly, only mortality, whereas not.