Growth inhibition by dehydrothyrsiferol - a non-Pgp modulator, derived from a marine red alga - in human breast cancer cell lines.
作者： MARTINA K Pec , KARIN Moser-Thier , JOSÉ J Fernandez , MARÍA L Souto , ERNST Kubista
DOI: 10.3892/IJO.14.4.739
关键词:
摘要: The novel marine terpenoid dehydrothyrsiferol (DHT) has been isolated from a Canarian red alga Laurencia viridis sp. nov (Ceramiales, Rhodomelaceae) (1). Its cytotoxicity against three human breast cancer cell lines, namely T47D, ZR-75-1, and Hs578T was examined compared with the chemotherapeutic compound doxorubicin mitosis-inhibitor colchicine. Primary carcinomas exhibit MDR1 gene expression (3). As investigated mammary lines did not rhodamine 123 efflux we proved in P-glycoprotein (Pgp) overexpressing epidermoid line that metabolite does modulate Pgp mediated drug transport. Therefore, it could be used expressing cells without interference.
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