Cisplatin-Stitched Polysaccharide Vesicles for Synergistic Cancer Therapy of Triple Antagonistic Drugs
作者： Nilesh Umakant Deshpande , Manickam Jayakannan
DOI: 10.1021/ACS.BIOMAC.6B01411
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摘要: New cisplatin-stitched polysaccharide vesicular nanocarrier is developed for combination therapy of three clinical important antagonistic drugs together to accomplish synergistic cancer in breast treatment. Carboxylic functionalized dextran was tailor-made the chemical conjugation cisplatin, and a renewable hydrophobic unit anchored backbone interdigitize chains self-assemble as nanovesicles. Water-soluble DNA-intercalating drug doxorubicin·HCl (DOX) water insoluble topoisomerase type I inhibitor camptothecin (CPT) were encapsulated these vesicles produce dual or triple drug-loaded nanocarrier. This unique DOX CPT stable aqueous medium, geometry acted shield Pt-polymer conjugate against glutathione (GSH) detoxification under physiological conditions. Lysosomal enzymes ruptured nanovesicle exclusively at intr...
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