Biodegradable Block Copolymer Scaffolds for Loading and Delivering Cisplatin Anticancer Drug
作者： Bapurao Surnar , Pramod P. Subash , Manickam Jayakannan
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摘要: A carboxylic acid substituted amphiphilic diblock copolymer scaffold with a hydrophilic PEG-chain and hydrophobic biodegradable poly(caprolactone) (PCL), which forms cisplatin anti- cancer drug is reported herein. Cisplatin (cis-dichloro-diammine plati- num(II), CDDP) was anchored on the polymer backbone through Pt- OOC-PCL chemical linkage that enabled self-assembly of prodrug to produce 11010 nm nanoparticles in water. These loaded were characterized by dynamic light scattering, electron microscopy, X-ray diffraction. The polymer-drug conjugate burst instantaneously saline PBS release 35% for immediate administration. remaining retained underwent slow controlled deliver over period 6-7 d. In presence esterase enzyme; PCL aliphatic ester broke completely re- lease 100% drugs within few hours. This di- block design strategy opens up new platform cisplatin- delivery approach. drugs. also partially associated non- biodegradability C-C bond these acrylic or norbor- nene polymers under vivo (or vitro) conditions. Thus, polymeric scaffolds are capable de- livering very much demand treatment.
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