Polymer Topology Driven Enzymatic Biodegradation in Polycaprolactone Block and Random Copolymer Architectures for Drug Delivery to Cancer Cells
作者： Mehak Malhotra , Bapurao Surnar , Manickam Jayakannan
DOI: 10.1021/ACS.MACROMOL.6B01793
关键词:
摘要: The present investigation reports polymer topology design principle for programming the enzymatic biodegradation and delivery of anticancer drugs at intracellular compartments breast cervical cancers. To accomplish this goal, new classes biodegradable amphiphilic block random copolymers based on hydrophilic carboxylic-functionalized polycaprolactone (CPCL) hydrophobic (PCL) units were designed via ring-opening polymerization methodology. interchain interactions their packing directly controlled by polymers, found to be as semicrystalline materials. These polymers readily dispersible in water, they self-assembled into <200 nm nanoparticles. nanoparticles exhibited excellent capability loading drug doxorubicin (DOX) pocket. In vitro release kinetics revealed that nanoscaffolds stable under physiological condi...
acs.org
figshare.com 
sci-hub.se 参考文章(51)
Bapurao Surnar, Pramod P. Subash, Manickam Jayakannan, Biodegradable Block Copolymer Scaffolds for Loading and Delivering Cisplatin Anticancer Drug Zeitschrift für anorganische und allgemeine Chemie. ,vol. 640, pp. 1119- 1126 ,(2014) , 10.1002/ZAAC.201400030
J. Rieger, K. V. Bernaerts, F. E. Du Prez, R. Jérôme, C. Jérôme, Lactone end-capped poly(ethylene oxide) as a new building block for biomaterials Macromolecules. ,vol. 37, pp. 9738- 9745 ,(2004) , 10.1021/MA048768H
Abdullah Mahmud, Sarthak Patel, Ommoleila Molavi, Phillip Choi, John Samuel, Afsaneh Lavasanifar, Self-Associating Poly(ethylene oxide)-b-poly(α-cholesteryl carboxylate-ε-caprolactone) Block Copolymer for the Solubilization of STAT-3 Inhibitor Cucurbitacin I Biomacromolecules. ,vol. 10, pp. 471- 478 ,(2009) , 10.1021/BM800846A
Yixiang Dong, Susan Liao, Michelle Ngiam, Casey K. Chan, Seeram Ramakrishna, Degradation behaviors of electrospun resorbable polyester nanofibers. Tissue Engineering Part B-reviews. ,vol. 15, pp. 333- 351 ,(2009) , 10.1089/TEN.TEB.2008.0619
P. S. Pramod, Kathryn Takamura, Sonali Chaphekar, Nagaraj Balasubramanian, M. Jayakannan, Dextran Vesicular Carriers for Dual Encapsulation of Hydrophilic and Hydrophobic Molecules and Delivery into Cells Biomacromolecules. ,vol. 13, pp. 3627- 3640 ,(2012) , 10.1021/BM301583S
Shuai Shi, Kun Shi, LiWei Tan, Ying Qu, GuoBo Shen, BingYang Chu, Shuang Zhang, XiaoLan Su, XingYi Li, YuQuan Wei, ZhiYong Qian, The use of cationic MPEG-PCL-g-PEI micelles for co-delivery of Msurvivin T34A gene and doxorubicin. Biomaterials. ,vol. 35, pp. 4536- 4547 ,(2014) , 10.1016/J.BIOMATERIALS.2014.02.010
Zhishen Ge, Shiyong Liu, Functional block copolymer assemblies responsive to tumor and intracellular microenvironments for site-specific drug delivery and enhanced imaging performance Chemical Society Reviews. ,vol. 42, pp. 7289- 7325 ,(2013) , 10.1039/C3CS60048C
Maria Ann Woodruff, Dietmar Werner Hutmacher, The return of a forgotten polymer—Polycaprolactone in the 21st century Progress in Polymer Science. ,vol. 35, pp. 1217- 1256 ,(2010) , 10.1016/J.PROGPOLYMSCI.2010.04.002
Friederike von Burkersroda, Luise Schedl, Achim Göpferich, Why degradable polymers undergo surface erosion or bulk erosion. Biomaterials. ,vol. 23, pp. 4221- 4231 ,(2002) , 10.1016/S0142-9612(02)00170-9
Reina Verónica Castillo, Alejandro J. Müller, Jean-Marie Raquez, Philippe Dubois, Crystallization Kinetics and Morphology of Biodegradable Double Crystalline PLLA-b-PCL Diblock Copolymers Macromolecules. ,vol. 43, pp. 4149- 4160 ,(2010) , 10.1021/MA100201G