Oral Supplementation of the Vitamin D Metabolite 25(OH)D3 Against Influenza Virus Infection in Mice.
作者： Hirotaka Hayashi , Masatoshi Okamatsu , Honami Ogasawara , Naoko Tsugawa , Norikazu Isoda
DOI: 10.3390/NU12072000
关键词:
摘要: Vitamin D is a fat-soluble vitamin that metabolized by the liver into 25-hydroxyvitamin [25(OH)D] and then kidney 1,25-dihydroxyvitamin [1,25(OH)2D], which activates receptor expressed in various cells, including immune for an overall immunostimulatory effect. Here, to investigate whether oral supplementation of D3 [25(OH)D3], major form metabolite 25(OH)D, has prophylactic effect on influenza A virus infection, mice were fed diet containing high dose 25(OH)D3 challenged with virus. In lungs 25(OH)D3-fed mice, viral titers significantly lower than standardly mice. Additionally, proinflammatory cytokines IL-5 IFN-γ downregulated after infection while anti-inflammatory not upregulated. These results indicate suppresses production inflammatory reduces replication clinical manifestations mouse model.
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