HL-A antigens as markers for disease susceptibility and autoimmunity in Graves' disease.

摘要: ABSTRACT Evidence for genetic control of susceptibility to Graves disease was sought using the human major histocompatibility (HL-A) antigens as markers. HL-A typing and assays antithyroglobulin (anti-Tg) anti-(thyroid)-microsomal (anti-M) autoantibodies were performed on 62 unrelated Caucasian patients with Graves' 113 normal controls. The frequency HL-A8 antigen in patient population increased 47% compared 21% controls (p < 0.0009) 0% a previously reported group post irradiation disease. findings demonstrate that may be useful markers and, fact, represent different pathogenetic processes. It is proposed linked immune response genes provide common explanation associations observed between thyroidal species locus both pres...