NPH insulin. Effective mixing - effective dose regimen

摘要: Insulin therapy, a corner stone of the treatment diabetes mellitus, both type 1 and 2, has undergone substantial modification since manufacture first insulin preparations 90 years ago up to present time. Human insulins, such as neutral protamin Hagedorn (NPH) remain major instrument therapy mellitus despite rapid developments in this field knowledge wide availability analogs. When prescribing these preparations, attending physician should be absolutely confident that patient minimum background skills indispensable for efficacious safe treatment. Such include habit mixing NPH suspensions by 20-fold turning vial or cartridge upside-down rolling them between palms order ensure uniform distribution suspension its accurate dosing. The manufactures place from one three glass metal bullets inside vials cartridges more homogeneous their contents. P. Kaiser et al. undertook study several pharmaceutical forms manufactured different companies estimate accuracy dosing (variability dose depending on number turns mixing). concentration single was measured high-performance liquid chromatography. Marked variability after less than ten (three six) documented all with exception Insuman Basal ("Sanofi"). It may expected will not deteriorate using owing presence heavy even if does perform necessary procedure another reason.