A diabetic life before and after the insulin era.

作者: J. M. Brostoff , H. Keen , J. Brostoff

DOI: 10.1007/S00125-007-0641-0

关键词:

摘要: To the Editor: Before introduction of insulin, a person with acute-onset diabetes had short life expectancy and died in ketoacidosis. We report case our greatgrandfather (J. M. Brostoff) grandfather respectively, who was diagnosed 1909, at age 29 years. He survived by diet treatment alone, aided strength will, for 14 years, one first patients UK to receive insulin August 1923; British-made having been released July that year. lived 88 robust health, no overt signs microvascular or macrovascular pathology. In 1909 previously lean healthy 29-year-old, 186 cm tall, presented his general practitioner 3-month history polydipsia, polyuria weight loss. A urine sample immediately turned brick red when boiled Benedict’s solution, diagnosis mellitus made. The patient informed limited, he should ‘make arrangements’. As father five young children (none whom subsequently developed diabetes), determined fight disease, even though time acute onset less than 4 years from (Fig. 1) [1]. His step travel see Kaiser’s physician Berlin, prescribed strict dramatically reduced carbohydrate content, whereas fat intake greatly increased. advised eat fried bacon because its high content and, despite Jewish faith, carried this out. result lost 32 kg weight. also make annual visits Bad Neuenahr-am-Rhein, where waters were said be especially beneficial people diabetes. Here regained 3 until return rather quickly war broke out 1914. health slowly deteriorating, went on Allen diet. This rigorous regimen involved restriction total food energy 1,000 kcal (4,190 kJ) per day, an added weekly 36-h fast. Although brought him brink collapse, would still retire bed Saturday evening flask coffee, appear again Monday morning. However, did have give up work as tailor period. Following consultation Dr Otto Leyton 1916 changed absolutely sugar-free, able resume Diabetologia (2007) 50:1351–1353 DOI 10.1007/s00125-007-0641-0

参考文章(5)
Stefan S. Fajans, Graeme I. Bell, Kenneth S. Polonsky, Molecular Mechanisms and Clinical Pathophysiology of Maturity-Onset Diabetes of the Young The New England Journal of Medicine. ,vol. 345, pp. 971- 980 ,(2001) , 10.1056/NEJMRA002168
S. C. Bain, G. V. Gill, P. H. Dyer, A. F. Jones, M. Murphy, K. E. Jones, C. Smyth, A. H. Barnett, Characteristics of type 1 diabetes of over 50 years duration (the Golden Years Cohort) Diabetic Medicine. ,vol. 20, pp. 808- 811 ,(2003) , 10.1046/J.1464-5491.2003.01029.X
Elliott P. Joslin, The unknown diabetic. Postgraduate Medicine. ,vol. 4, pp. 302- 306 ,(1948) , 10.1080/00325481.1948.11693701