Fate of the nonsteroidal, anti-inflammatory veterinary drug flunixin in agricultural soils and dairy manure.

摘要: A large percentage of flunixin, a nonsteroidal anti-inflammatory drug widely used for treating livestock, is excreted in intact form and thus potentially available environmental transport. As the fate flunixin environment unknown, our objective was to quantify sorption, desorption, transformation five agricultural soils manure using batch equilibrium methods. Concentrations degradation products were determined by high performance liquid chromatography time flight mass spectrometry. For all studied soils, sorption exhibited linear character, with both Freundlich models providing adequate fit. Linear coefficients varied from 8 112 L kg−1. The strongest Pearson correlations clay content (r = 0.8693), total nitrogen (r = 0.7998), organic carbon (r = 0.6291). Desorption reversibly bound fraction (3–10% sorbed flunixin) non-hysteretic character suggesting low affinity this soil. Flunixin relatively slow, exhibiting half-lives 39–203 days, off-site transport contamination. biological impacts at environmentally relevant concentrations must be given its behavior extensive use as livestock.