Bcl-2 and bax protein expression in indolent versus aggressive B-cell non-hodgkin's lymphomas

摘要: Bcl-2 and bax are cellular proteins that important in the regulation of apoptosis. Overexpression bcl-2 protein is associated with prolonged cell survival, whereas overexpression correlates increased apoptosis after injury. It has been suggested ratio determines a cell's susceptibility to We studied expression by immunohistochemical methods 46 cases B-cel non-Hodgkin's lymphoma characterized Revised European-American Lymphoma (REAL) classification determine whether these two correlated histological subtype or predicted clinical behavior (indolent v aggressive). For each case, both percentage cells staining as well intensity were recorded, bcl-2-bax (BBPR) was calculated. Bax identified 100% lymphomas studied. In contrast, seen only 67%. positive small lymphocytic lymphomas, 80% follicle center 38% diffuse large 33% high-grade B-cell Burkitt's-like 0% Burkitt's lymphoblastic lymphomas. The BBPR indolent (mean, 1.8) significantly greater than aggressive 0.6) (P < = .002). This suggests may be linked biological