Expression of cyclin D3 and cyclin E and identification of distinct clusters of proliferation and apoptosis in diffuse large B-cell lymphomas.
作者： V. Galani , A. Chaidos , A. Skyrlas , N. J. Agnantis , E. Tsanou
DOI: 10.14670/HH-18.449
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摘要: In the present study 79 cases of de novo Diffuse Large B-cell Lymphomas (DLBCL) were studied in order: a) to analyse expression cyclin D3, E and D1 relation other proliferative features (expression Ki67, A B1), apoptosis status p53, Rb, p16 p27; b) determine whether distinct clusters proliferation could be identified DLBCL. Overexpression D3 was found 35/79 (43%) 18/79 (22%) cases, respectively, whereas overexpression not detected any case. most (39/46) mutually exclusive possibly reflecting different underlying pathways inducing deregulated these cyclins. (29/35) with Rb/p16 aberrant supporting an oncogenic role for suggesting that pathogenetic effect occurs through perturbation Rb1 pathway. Combined alterations P53 Rb/p16/cyclin significantly associated higher mean values (p=0.023) B1 (p=0.033) indicating concurrent impairment p53 induces increased tumour cell Cluster analysis permitted separation DLBCL into groups low (44 cases) high (18 apoptotic activity (32 cases), intermediate (36 (11 activity. The identification respect indicates cellular kinetic properties can defined histological group
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