The Pezcoller lecture: cancer cell cycles revisited.
作者： Charles J. Sherr
DOI:
关键词: Retinoblastoma protein 、 Cyclin E 、 Cyclin A2 、 Cyclin A 、 Cyclin B 、 Biology 、 Cyclin-dependent kinase 、 Cyclin D 、 Cancer research 、 Cyclin D1
摘要: … Once … to enter the cycle from G 0 , they generally require continuous mitogenic stimulation to be driven to the restriction point, after which mitogens can be withdrawn and cells will enter …
aacrjournals.org
researchgate.net 参考文章(119)
M. Kitagawa, H. Higashi, H. K. Jung, I. Suzuki-Takahashi, M. Ikeda, K. Tamai, J. Kato, K. Segawa, E. Yoshida, S. Nishimura, Y. Taya, The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2. The EMBO Journal. ,vol. 15, pp. 7060- 7069 ,(1996) , 10.1002/J.1460-2075.1996.TB01097.X
J-Y Kato, H Matsushime, SW Hiebert, ME Ewen, CJ Sherr, Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4. Genes & Development. ,vol. 7, pp. 331- 342 ,(1993) , 10.1101/GAD.7.3.331
J R Nevins, Toward an understanding of the functional complexity of the E2F and retinoblastoma families. Cell Growth & Differentiation. ,vol. 9, pp. 585- 593 ,(1998)
Marion A. E. Lohrum, Margaret Ashcroft, Michael H. G. Kubbutat, Karen H. Vousden, Identification of a cryptic nucleolar-localization signal in MDM2 Nature Cell Biology. ,vol. 2, pp. 179- 181 ,(2000) , 10.1038/35004057
Ignacio Palmero, Cristina Pantoja, Manuel Serrano, p19ARF links the tumour suppressor p53 to Ras Nature. ,vol. 395, pp. 125- 126 ,(1998) , 10.1038/25870
Matthew L. Fero, Erin Randel, Kay E. Gurley, James M. Roberts, Christopher J. Kemp, The murine gene p27Kip1 is haplo-insufficient for tumour suppression Nature. ,vol. 396, pp. 177- 180 ,(1998) , 10.1038/24179
Lewis Thomas, The Medusa and the Snail: More Notes of a Biology Watcher ,(1974)
F Zindy, C J Sherr, P J McKinnon, J A Diehl, T Kamijo, E van de Kamp, M J Chong, Loss of the ARF tumor suppressor reverses premature replicative arrest but not radiation hypersensitivity arising from disabled atm function. Cancer Research. ,vol. 59, pp. 2464- 2469 ,(1999)
Jason D. Weber, Laura J. Taylor, Martine F. Roussel, Charles J. Sherr, Dafna Bar-Sagi, Nucleolar Arf sequesters Mdm2 and activates p53 Nature Cell Biology. ,vol. 1, pp. 20- 26 ,(1999) , 10.1038/8991
David Sidransky, Geoffrey I. Shapiro, Christian D. Edwards, Li Mao, Barrett J. Rollins, Gauri Bedi, Adrian Merlo, A Novel p16INK4A Transcript Cancer Research. ,vol. 55, pp. 2995- 2997 ,(1995)