Experimental Approaches to Restoration of Function of Ascending and Descending Axons in Spinal Cord Injury

摘要: In many cases of spinal cord injury (SCI) (even in some clinically “complete” nonpenetrating SCI), there is a subpopulation axons that survive. These residual are not transected, but fail to conduct normal action potentials as result demyelination; they display conduction block or slowing. Recognition the existence these spared and identification demyelination significant factor contributing their dysfunction have triggered an important shift our thinking about restoration function SCI. addition examining regrowth severed within cord, contemporary SCI research thus focusing on axonal demyelinated axons. This chapter reviews background this approach well recent developments suggest new strategies for following trauma.