Formation and Metabolism of Testosterone in Testicular Tissue of Immature Rats

摘要: Testicular tissue from newborn, 20- and 90-day-old rats was incubated with radiolabeled testosterone or androstenedione. Tissue newborn adult actively metabolized androstenedione (75–80 % conversion), being the major product. Testosterone, on other hand, poorly metabolized, only 10–20 converted to In incubates of testicular 20-day-old rats, both were primarily (70–80%) 5α-reduced androgens. The addition heparin almost completely blocked formation androgens in indicating inhibition 5α-reductase by heparin. Incubation a similar system resulted accumulation minor androgens, suggesting that formed absence are, most likely, products testo...