Pharmacological evidence that methylene blue inhibits noradrenaline neuronal uptake in the rat vas deferens.
作者： Oduvaldo C. M. Pereira , Ricardo C. Custodio , Agnaldo B. Chies , Fernando M. A. Correa , Gregorio L. De Souza
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摘要: We report that the classical guanylate cyclase inhibitor methylene blue (MB, 1 microM or 10 microM), but not selective 1H-[1,2,4]oxidazolo[4,3-a]quinoxalin-1-one (1 microM) nitric oxide synthase inhibitor, NG-nitro-L-arginine methyl ester (100 causes a shift to left in concentration-response curve for noradrenaline isolated rat vas deferens preparations. The main objective of our study was investigate pharmacological mechanism by which MB increases sensitivity noradrenaline. According presented results, did change methoxamine presence desipramine (0.1 microM). pre-contracted relaxation induced isoproterenol also significantly changed Thus, we suggest through neuronal uptake inhibition without interfering either nitrergic activity.
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