Azithromycin and glucosamine may amplify the type 1 interferon response to RNA viruses in a complementary fashion.
作者： James J. DiNicolantonio , Jorge Barroso-Aranda , Mark F. McCarty
DOI: 10.1016/J.IMLET.2020.09.008
关键词:
摘要: Previous research demonstrates that, in clinically relevant concentrations, azithromycin can boost the ability of RNA viruses to induce type 1 interferon by amplifying expression and virally-mediated activation MDA5. O-GlcNAcylation MAVS, a down-stream target MDA5, renders it more effective for induction. High-dose glucosamine administration up-regulates increasing cellular pool UDP-N-acetylglucosamine. Hence, is proposed that joint high-dose glucosamine, early course virus infections, may interact complementary fashion aid their control enhancing
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