Ampullosporin, a new peptaibol-type antibiotic from Sepedonium ampullosporum HKI-0053 with neuroleptic activity in mice.
作者： MICHAEL RITZAU , STEPHAN HEINZE , KLAUSJÜRGEN DORNBERGER , ALBRECHT BERG , WERNER FLECK
DOI: 10.7164/ANTIBIOTICS.50.722
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摘要: Ampullosporin (I; Ac-Trp-Ala-Aib-Aib-Leu-Aib-Gln-Aib-Aib-Aib-Gln-Leu-Aib-Gln-Leuol) was isolated from the mycelium of Sepedonium ampullosporum as a new 15-membered peptaibol-type antibiotic. The structure determined by mass spectrometric and two-dimensional NMR experiments. displays narrow-spectrum antibacterial antifungal activity, induces pigment formation Phoma destructiva, causes hypothermia decreased spontaneous locomotor activity in mice dosages > 1 mg/kg.
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