Effects on infarct size and on arrhythmias by controlling reflow after myocardial ischaemia in pigs

摘要: Part of the myocardial damage after an ischaemic period might be related to reperfusion conditions. Many abrupt changes occurring in heart during may add preceding period, and increase infarct size. In this study we tested hypothesis that size occurrence ventricular arrhythmias reduced by restricting reflow period. Seventeen pigs underwent 45 min total occlusion left anterior descending coronary artery with hydraulic occluder. intervention group was restricted 50% baseline first minute, 100% next kept constant for 1 min, thereafter allowed flow every minute until free reflow. control not restricted. Arrhythmias were recorded. After 2.5 h excised. Infarct measured using triphenyltetrazolium chloride (delineation necrosis), fluorescent microspheres area at risk) planimetry. No reduction (% found between (75.9 +/- 5.3% vs. 72.4 4.3%). The incidence fibrillation different groups reperfusion. Hemodynamic parameters significantly two groups. Our data indicate no substantial protection against or could achieved controlling present protocol a ischaemia pigs. Accordingly, our do support notion beneficial when treating percutaneous angioplasty (PCA).