Studies of controlled reperfusion after ischemia. VII: High oxygen requirements of dyskinetic cardiac muscle

摘要: This study assesses the regional oxygen requirements of muscle segments that are beating and working, empty, arrested decompressed, nonischemic move dyskinetically. Regional demands were evaluated by producing a dyskinetic segment infusing cardioplegic solution through left anterior descending coronary artery catheter with without extracorporeal circulation. The results show O2 perfused cardiac (4 to 8 ml/100 gm/min) approximately 55% contracting (beating, working) (7 12 fivefold more than when same is decompressed total vented bypass (0.8 1.2 gm/min). Additional studies showed ischemia for 2 hours (left ligation) produced severe dyskinesia (–24% control systolic shortening), which failed recover after reperfusion heart in beating, working state. In contrast, lowering during restored occasional contractile function as consequence ventricular decompression. Dyskinetic have high requirement may affect their capacity be salvaged if conducted These observations (1) suggest value revascularization (i.e., streptokinase or angioplasty) limited unless ventricle (2) provide an explanation delayed recovery mechanical hearts reperfused surgically normal blood cardiopulmonary bypass.