Induction of apoptosis in MRC-5, diploid human fetal lung cells after infection with human coronavirus OC43.

摘要: Human coronaviruses (HCoV) cause upper respiratory tract infections manifested by symptoms of the common cold including rhinitis, tussis, fever, headache and myalgia (Hruskova et al 1990). HCoV illness is primarily virus-mediated; immunologic events have not been postulated to play a role (Makela 1998). Evidence showing presence viral genome in spinal fluid brain suggests that may an etiologic multiple sclerosis (Stewart 1992, Cristallo 1997). However, pathogenesis poorly understood. In human embryonic tracheal organ cultures, causes slow patchy destruction ciliated epithelial cells tissue cytopathic effect subtle, evident only vacuolization spindling.