Comparison of the effects of three kinds of IgYs, (normal, nanoliposomal and nanoparticle conjugated), which are produced against the small domains of DR5 protein on cancer cells.
作者： Shaghaegh Amirijavid , Maliheh Entezari
DOI: 10.1049/IET-NBT.2017.0123
关键词:
摘要: Cancer treatment with several kinds of drugs, especially targets the apoptotic pathways nowadays. TNF-related apoptosis-inducing ligand (TRAIL) as one important members death receptors, significantly trigger induction apoptosis in cancer cells. Three conserved domains Death receptor (DR5) protein extracellular domain, which are fortified cysteine, were chosen and chemically synthesised. Hens immunised nano-liposomal peptides, a result purified Immunoglobulin (IgYs) remarkably killed cancerous MCF7 The flow cytometric assay, confirmed death. Among carriers that used this research, nanoparticle conjugated, both acceptable choices for drug delivery. Furthermore, IgY against DR5's small peptides such successfully reached target cells via apoptosis.
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