Prescribing Patterns of Psychotropic Drugs and Risk of Violent Behavior: A Prospective, Multicenter Study in Italy.

摘要: BACKGROUND This prospective cohort study aimed at evaluating patterns of polypharmacy and aggressive violent behavior during a 1-year follow-up in patients with severe mental disorders. METHODS A total 340 (125 inpatients from residential facilities 215 outpatients) were evaluated baseline the Structured Clinical Interview for DSM-IV Axis I II, Brief Psychiatric Rating Scale, Specific Levels Functioning scale, Brown-Goodwin Lifetime History Aggression, Buss-Durkee Hostility Inventory, Barratt Impulsiveness State-Trait Anger Expression Inventory-2. Aggressive was rated every 15 days Modified Overt Aggression Scale treatment compliance Medication Adherence Scale. RESULTS The whole sample prescribed mainly antipsychotics high levels polypharmacy. Clozapine prescription higher associated lower behavior. Patients history violence who took clozapine highest number drugs. cumulative mean scores taking (n = 46), other (n = 257), no (n = 37) significantly different (P = .001). showed time trend (24 evaluations) indicating level Patient also ratings follow-up. CONCLUSION Both outpatients compared any or psychotropic Higher