Development of a new trend conjugate vaccine for the prevention of Klebsiella pneumoniae

摘要: Klebsiella pneumoniae is a major cause of nosocomial pneumonia, septicemia and urinary tract infections, especially in newborns, blood cancer patients, other immunocompromised candidates. The control K. complicated issue due to its tight pathogenesis. Immuno-prophylactic preparations, those directed toward the bacterium O-antigen, showed be most successful way prevent infection incidence. However, all previously proposed preparations were either limited spectrum or non-maternal, hence not targeting main patients. Moreover, only respiratory diseases that pathogen. This article addresses development method originally used purify non-capsular bacterial-endotoxins, as new easy for vaccine production against pneumoniae. application this was preceded by biotechnological capsular polysaccharide produced natural conjugate between bacterial O-antigen outer membrane proteins evaluated physicochemical immunological methods investigate purity, integrity, safety immunogenicity. It pure, stable, safe use, able elicit protective immunoglobulin titer different infections. immune-response proved transferable offspring vaccinated experimental rabbits via placenta.