Ubiquitin ligases and posttranslational regulation of energy in the heart: The hand that feeds
作者： David I. Brown , Traci L. Parry , Monte S. Willis
DOI: 10.1002/CPHY.C160024
关键词:
摘要: Heart failure (HF) is a costly and deadly syndrome characterized by the reduced capacity of heart to adequately provide systemic blood flow. Mounting evidence implicates pathological changes in cardiac energy metabolism as contributing factor development HF. While main source fuel healthy oxidation fatty acids, failing less efficient glucose glycogen are upregulated. The ubiquitin proteasome system plays key role regulating via protein-degradation/regulation autophagy metabolism-related transcription cell signaling processes. In this review, we discuss recent research that describes ubiquitin-proteasome (UPS) context We focus on ligases (E3s), component UPS confers substrate specificity, detail current understanding how these E3s contribute pathology metabolism. © 2017 American Physiological Society. Compr Physiol 7:841-862, 2017.
sci-hub.se 参考文章(179)
Jessica E. Rodríguez, Jie-Ying Liao, Jun He, Jonathan C. Schisler, Christopher B. Newgard, Doreen Drujan, David J. Glass, C. Brandon Frederick, Bryan C. Yoder, David S. Lalush, Cam Patterson, Monte S. Willis, The ubiquitin ligase MuRF1 regulates PPARα activity in the heart by enhancing nuclear export via monoubiquitination. Molecular and Cellular Endocrinology. ,vol. 413, pp. 36- 48 ,(2015) , 10.1016/J.MCE.2015.06.008
Weiwei Wu, Hao Xu, Zemin Wang, Yun Mao, Liangshuai Yuan, Wei Luo, Zhaoqiang Cui, Taixing Cui, Xing Li Wang, Ying H. Shen, PINK1-Parkin-Mediated Mitophagy Protects Mitochondrial Integrity and Prevents Metabolic Stress-Induced Endothelial Injury PLOS ONE. ,vol. 10, pp. e0132499- ,(2015) , 10.1371/JOURNAL.PONE.0132499
Dake Qi, Lawrence H. Young, AMPK: energy sensor and survival mechanism in the ischemic heart Trends in Endocrinology and Metabolism. ,vol. 26, pp. 422- 429 ,(2015) , 10.1016/J.TEM.2015.05.010
Megan T. Quintana, Jun He, Jenyth Sullivan, Trisha Grevengoed, Jonathan Schisler, Yipin Han, Joseph A. Hill, Cecelia C. Yates, William E. Stansfield, Rudo F. Mapanga, M. Faadiel Essop, Michael J. Muehlbauer, Christopher B. Newgard, James R. Bain, Monte S. Willis, Muscle ring finger-3 protects against diabetic cardiomyopathy induced by a high fat diet BMC Endocrine Disorders. ,vol. 15, pp. 36- 36 ,(2015) , 10.1186/S12902-015-0028-Z
Monte S. Willis, Kristine M. Wadosky, Jessica E. Rodríguez, Jonathan C. Schisler, Pamela Lockyer, Eleanor G. Hilliard, David J. Glass, Cam Patterson, Muscle ring finger 1 and muscle ring finger 2 are necessary but functionally redundant during developmental cardiac growth and regulate E2F1-mediated gene expression in vivo. Cell Biochemistry and Function. ,vol. 32, pp. 39- 50 ,(2014) , 10.1002/CBF.2969
Pravir Kumar, Kaveri Pradhan, R. Karunya, Rashmi K. Ambasta, Henry W. Querfurth, Cross-functional E3 ligases Parkin and C-terminus Hsp70-interacting protein in neurodegenerative disorders Journal of Neurochemistry. ,vol. 120, pp. 350- 370 ,(2012) , 10.1111/J.1471-4159.2011.07588.X
Patrice Connell, Carol A. Ballinger, Jihong Jiang, Yaxu Wu, Larry J. Thompson, Jörg Höhfeld, Cam Patterson, The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins. Nature Cell Biology. ,vol. 3, pp. 93- 96 ,(2001) , 10.1038/35050618
Jun He, Megan T Quintana, Jenyth Sullivan, Traci L Parry, Trisha J Grevengoed, Jonathan C Schisler, Joseph A Hill, Cecelia C Yates, Rudo F Mapanga, M Faadiel Essop, William E Stansfield, James R Bain, Christopher B Newgard, Michael J Muehlbauer, Yipin Han, Brian A Clarke, Monte S Willis, MuRF2 regulates PPARγ1 activity to protect against diabetic cardiomyopathy and enhance weight gain induced by a high fat diet Cardiovascular Diabetology. ,vol. 14, pp. 97- 97 ,(2015) , 10.1186/S12933-015-0252-X
Michael E. Walsh, Arunabh Bhattacharya, Kavithalakshmi Sataranatarajan, Rizwan Qaisar, Lauren Sloane, Md M. Rahman, Michael Kinter, Holly Van Remmen, The histone deacetylase inhibitor butyrate improves metabolism and reduces muscle atrophy during aging Aging Cell. ,vol. 14, pp. 957- 970 ,(2015) , 10.1111/ACEL.12387
Rohit A Sinha, Brijesh K Singh, Jin Zhou, Yajun Wu, Benjamin L Farah, Kenji Ohba, Ronny Lesmana, Jessica Gooding, Boon-Huat Bay, Paul M Yen, Thyroid hormone induction of mitochondrial activity is coupled to mitophagy via ROS-AMPK-ULK1 signaling Autophagy. ,vol. 11, pp. 1341- 1357 ,(2015) , 10.1080/15548627.2015.1061849