Evaluation of human neutrophil peptide-1, -2 and -3 as serum markers for colorectal cancer
作者： Irene van den Broek , Rolf W. Sparidans , Judith Y.M.N Engwegen , Annemieke Cats , Annekatrien C.T.M. Depla
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摘要: Increased total serum concentrations of human neutrophil peptide-1, -2 and -3 (HNP-1, -3) have been associated with colorectal cancer (CRC). Owing to a recently developed fully validated liquid-chromatography coupled tandem-mass spectrometry (LC-MS/MS) assay, individual these antimicrobial peptides were quantified evaluate their role as markers in CRC. Serum was obtained from patients indications for colonoscopy, subsequently diagnosed normal colon or hyperplastic polyp (CON; n= 368), adenomatous (AP; n = 179) (CRC; 69). Comparison HNP-1, between CRC CON (130 ± 90 vs. 105 80; 264 140 206 99 62 56 54 59 -3, respectively) revealed that reported up-regulated HNP-concentrations can be largely attributed increased HNP-2 (P=0.0006) HNP-1 (P=0.024) levels. Although receiver operating characteristics (ROC) analyses showed low specificity the no significant changes levels observed after surgical removal tumor (n=23), established differentiation HNP-subtypes may particularly useful completely elucidate
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