Prostacyclin and iloprost do not affect action of standard dose heparin on haemostatic function during haemodialysis

摘要: Abstract The actions of prostacyclin and iloprost, as supplements to heparin therapy, were examined by measuring indices blood coagulation platelet activation during the first two hours haemodialysis in six patients with stable chronic renal failure. Patients received either 5 ng kg −1 min , iloprost 2 or placebo at random on three separate occasions a supplement standard therapy 50 I.U. loading dose 30 hr infusion. Neither nor significantly affected dialysis induced changes whole count plasma concentrations β thromboglobulin, (βTG) factor 4 (PF4), fibrinogen fibrinopeptide A. Thus still fell 12 ± 8% within 15 start dialysis, slowly returning initial over study period PF4 increased nearly 10 fold same time. In addition, serial measurements KCCT failed indicate any sparing effect prostanoids this heparin.