Catalysis, kinetics and mechanisms of organo-iridium enantioselective hydrogenation-reduction

摘要: The synthesis of chiral molecules is great importance to the pharmaceutical, agrochemical, flavour and fragrance industries. use organo-iridium complexes has gained a reputation for its utility in key enantioselective synthetic procedures. Prime examples include catalytic reduction carbonyls imines; iridium-catalysed allylic substitution catalysed hydrogenation unsaturated carboxylic acids. Important aspects these processes are reaction conditions such as catalyst loading, metal-ion ligands, substrate, solvent times-all which can affect degree enantioselectivity. Understanding mechanisms hydrogenation/reduction reactions through kinetic other related studies makes vital contribution improving efficiency.