Oxygen transport characterization of a human model of progressive hemorrhage.

摘要: Abstract Background Hemorrhage continues to be a leading cause of death from trauma sustained both in combat and the civilian setting. New models hemorrhage may add value improving our understanding physiologic responses severe bleeding as platforms develop test new monitoring therapeutic techniques. We examined changes oxygen transport produced by central volume redistribution humans using lower body negative pressure (LBNP) potential mimetic hemorrhage. Methods results In 20 healthy volunteers, systemic delivery consumption, skeletal muscle oxygenation oral mucosa perfusion were measured over increasing levels LBNP point hemodynamic decompensation. With sequential reductions blood volume, progressive tissue parameters noted, while no observed uptake or markers anaerobic metabolism (e.g., lactate, base excess). While decreased heart rate increased during LBNP, these occurred later than perfusion. Conclusions These findings indicate that induces consistent with compensatory phase hemorrhage, but frank state shock (delivery-dependent consumption) does not occur. therefore serve model better understand variety physiological occur pre-shock conscious humans. As such, useful platform which capabilities for identifying need intervention early phases prevent patient's progression overt shock.