Therapy-induced polyploidization and senescence: Coincidence or interconnection?

作者: Ewa Sikora , Joanna Czarnecka-Herok , Agnieszka Bojko , Piotr Sunderland

DOI: 10.1016/J.SEMCANCER.2020.11.015

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摘要: Abstract Polyploid somatic cells have ‘programmed’ roles in normal development and stress responses. Transient polyploidy states been observed several tumor types at early stages of tumorigenesis. They can give rise to the aneuploidy state which is a common feature human cancer cells. Similarly, development, treatment lead transient polyploidy. giant (PGCCs) are often associated with poor prognosis disease relapse. Cancer cell senescence- proliferation arrest accompanied by set characteristic markers- induced therapy also formation The question whether therapy-induced senescence (TIS) (TIP) mechanistically or coincidentally connected. This problem needs be solved rather urgently, because TIS appears more phenomena than originally believed. Another arising concerns reversibility as consequence atypical divisions polyploid In our review we will try answer this fundamental referring published literature own studies.

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