Effect of Colchicine on 45Ca and Choline Uptake, and Acetylcholine Release in Rat Brain Synaptosomes
作者： M. E. O'Leary , J. B. Suszkiw
DOI: 10.1111/J.1471-4159.1983.TB08115.X
关键词:
摘要: The effects of 1 and 10 mM colchicine on the K+-evoked release preformed newly synthesized acetylcholine K+-depolarization-stimulated uptake 45Ca were compared in rat brain synaptosomes. Preincubation synaptosomes with had little effect transmitter 45Ca; inhibited both by 58%. Since has been shown to disaggregate intrasynaptosomal microtubules almost completely, but be without either or our experiments, it is concluded that modifies reducing Ca2+ influx, rather than its postulated intracellular action microtubule-mediated mobilization. In addition, cholchicine significantly high-affinity choline This hemicholinium-like may contribute reduction release.
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