NKT Cells in Tumor Immunity

摘要: NKT cells are a small subset of true T that bridge between the innate and adaptive immune systems, provide cellular system with means to recognize lipid antigens, interact regulate other parts system. In particular, they tumor immunity both positively negatively. They defined by their recognition antigens presented nonclassical MHC molecule CD1d, rather than conventional class I or II molecules. Classical type use semi-invariant cell receptor conserved alpha chain in mice humans, alpha-galactosylceramide its homologues, generally promote immunity. Type diverse receptors, lipids such as sulfatide, usually suppress These two subsets also cross-regulate each influence immunoregulatory cells. The balance along axis can have profound effects on immunosurveillance immunity, well vaccine responses. Harnessing these fight cancer is being undertaken clinical trials beginning show promise.