Topical chemoprevention of skin cancer in mice, using combined inhibitors of 5-lipoxygenase and cyclo-oxygenase-2

摘要: Objective: Skin cancer is the most common cancer, and often occurs in head neck region. This study aimed to investigate whether a combination of inhibitors cyclo-oxygenase-2 5-lipoxygenase, applied via microemulsion delivery system, would be effective topically inhibiting skin carcinogenesis. Study design: Randomised animal study. Methods: Twenty-four nude mice were intradermally inoculated with carcinoma cells then divided into three groups (eight animals each): group one received no treatment; two celecoxib alone; zileuton celecoxib. Tumour incidence growth measured for 14 days. Results: Both treatments significantly delayed onset development tumours. However, combined treatment had best response ( p Conclusion: The results clearly showed that topical either alone or plus inhibited carcinogenesis, both agents results.