Topical delivery of celecoxib using microemulsion.

摘要: The topical delivery of celecoxib has been studied using microemulsion as the vehicle for treatment UV B induced skin cancer. Pseudotemary phase diagrams were constructed at different oil to cosurfactant ratios identify formulation variables formation, and effect these on permeation was evaluated with excised rat skin. Topical anti-inflammatory assessed arachidonic acid ear oedema model. Formulation E consisting 3% celecoxib, 22% propylene glycol dicaprylate/dicaprate + caprylic/capric mono-/di-glycerides (2:1), 30% polysorbate 80 water (all w/w) showed higher rate significant activity. formulations have a prospect use potential