Influence of Diabetes Mellitus and Cigarette Smoking on Variability of the Clopidogrel-Induced Antiplatelet Effect and Efficacy of Active Management of the Target P2Y12 Reaction Unit Range in Patients Undergoing Neurointerventional Procedures.
作者： Ichiro Nakagawa , Hun Soo Park , Shohei Yokoyama , Takeshi Wada , Yasuo Hironaka
DOI: 10.1016/J.JSTROKECEREBROVASDIS.2015.09.010
关键词:
摘要: Background Optimal antiplatelet inhibition is essential in patients undergoing neurointerventional procedures; however, variability response to clopidogrel can contribute thromboembolic and hemorrhagic complications. The present study evaluated the influence of diabetes mellitus cigarette smoking on reactivity. Methods Between 2011 2013, 71 consecutive underwent aneurysmal coil embolization (CE) or carotid artery stenting (CAS) received (75 mg daily) aspirin (100 mg before treatment. were divided into 2 groups: CE (n = 31) CAS (n = 40). prospective assessment preoperative platelet function using VerifyNow assay adjunctive cilostazol (200 mg daily, triple therapy) case hyporesponse. Patients with hyper-response dose reduction (clopidogrel, 12.5-50 mg daily). Results Clopidogrel resistance was noted 15 (37.5%) group 4 (12.9%) ( P = .031). (5%) 11 (54.8%) Conclusions Significant differences baseline clinical characteristics when comparing endovascular treatment unruptured cerebral aneurysms stenosis. Diabetes current smoker status independent factors related reactivity clopidogrel.
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