Endothelin receptors, second messengers, and actions in bone.

摘要: Endothelins are a class of peptides that produced by and elicit responses in many tissues. A growing literature documents the presence effects endothelins bone. Both endothelinA endothelinB receptors have been demonstrated osteoblastic cells ligand binding. Major signal transduction pathways for endothelin bone appear to be stimulation phospholipid turnover, activation A, C D phospholipases, calcium flux from intracellular extracellular stores tyrosine kinases. also modulate signaling elicited other agents cells. The parathyroid hormone-stimulated transient UMR-106 is enhanced endothelins, acting through an receptor, whereas increase cyclic AMP inhibited endothelins. Phenotypic endothelin-1 include changes alkaline phosphatase activity, osteocalcin osteopontin message, collagen noncollagenous protein synthesis, inhibition osteoclast motility prostaglandin-dependent resorption. Endothelin-1 enhances interleukin-1-induced interleukin-6. can potentially affect metabolism their actions inhibit secretion hormone.